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Anti-NTN1 Antibody

Rabbit monoclonal antibody

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BM5661

  • 50μl ¥1180 100μl ¥1960 150μl ¥2780
  • 货期: 5-7天
  • Western blot analysis of Netrin 1 expression in Human fetal brain lysate.

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  • All lanes use the Antibody for 1 hour at room temperature.

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产品名称
Anti-NTN1 Antibody
规格/价格
50μl/1180 100μl/1960 150μl/2780
指标别称
netrin 1; NTN1; NTN1L
产品类型
Monoclonal
检验物种
human, mouse, rat
应用范围
WB, ICC/IF
基因名称
NTN1
宿主
Rabbit
抗体亚型
IgG
免疫原
A synthesized peptide derived from human Netrin 1
计算分子量
68 kDa
实际分子量
75 kDa
成分
500 ug/ml; Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide, 0.4-0.5 mg/ml BSA and 50% glycerol.
纯化方式
Affinity-chromatography
浓度
500 ug/ml
产品形态
Liquid
保存条件
12 months from date of receipt,-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.
背景资料
Netrin-1(NTN1), also known as NTN1L, is a diffusible protein made by floor plate cells. Netrin-1 is found in the floor plate and neuroepithelial cells of the ventral region of the spinal cord, as well as other locations in the nervous system including the somatic mesoderm, pancreas and cardiac muscle. The human NTN1 gene is mapped to chromosome 17p13-p12 by FISH. Netrin-1 can attract spinal commissural axons and repel trochlear axons in vitro. And netrin-1 expression confers a selective advantage for tumor cell survival. The binding of netrin-1 to DCC appears to depend on the presence of a coreceptor or accessory proteins. Adenosine A2b receptor is actually a netrin-1 receptor and induces cAMP accumulation on binding netrin-1, and that netrin-1-dependent outgrowth of dorsal spinal cord axons directly involves A2b. Netrin-1 can promote intestinal tumor development, probably by regulating cell survival. Thus, a netrin-1 receptor or receptors function as conditional tumor suppressors. Expression of Unc5b triggered endothelial cell repulsion in response to netrin-1 in vitro, whereas a truncated Unc5b lacking the intracellular signaling domain failed to induce repulsion.
Uniprot ID
O95631  
文献引用格式
NTN1 Antibody (Boster Biological Technology, Wuhan, China. Catalog#BM5661)
应用释义
WB- 蛋白质免疫印迹法,IHC- 免疫组织化学法,ICC/IF-免疫细胞荧光,ICC-免疫细胞化学,IHC-F- 冰冻切片免疫组化,FCM-流式细胞术,ELISA-酶联免疫吸附测定,IP-免疫沉淀法 ,IF-免疫组织荧光法,ChIP-染色质免疫沉淀法
推荐稀释比
Western blot (WB):1:500-2000
Immunocytochemistry/Immunofluorescence (ICC/IF):1:50-200

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