Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody (Clone#OTI7A7)

Mouse monoclonal antibody

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筛选器： All IHC

M00029-2

50μl ￥1280 100μl ￥2180 150μl ￥2800
货期： 5-7天

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Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-PIK3CA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris, pH8.5, 120°C for 3min, M00029-2)
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产品名称

Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody (Clone#OTI7A7)

规格/价格

50μl/1280 100μl/2180 150μl/2800

指标别称

p110 alpha; PI3 kinase subunit alpha; PI3K; PI3K alpha; PI3K p110(alpha); PIK3CA; PtdIns 3 kinase subunit alpha

产品类型

Monoclonal

检验物种

human, mouse, rat

应用范围

IHC

基因名称

PIK3CA

克隆号

OTI7A7

宿主

Mouse

抗体亚型

IgG2a

免疫原

Human recombinant protein fragment corresponding to amino acids 303-631 of human PIK3CA (NP_006209) produced in E.coli.

实际分子量

124.1KD

成分

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

纯化方式

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

浓度

500 ug/ml

产品形态

Liquid

保存条件

Stable for 12 months from date of receipt. Store at -20°C as received.

背景资料

Phosphatidylinositol-4,5-bisphosphate 3-kinase, also called PIK3CA, is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. PIK3CA gene is mapped to 3q26.32. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate phosphatidylinositols (PtdIns), PtdIns4P andPtdIns(4,5)P2. Recent evidence has shown that the PIK3CA gene is mutated in a range of human cancers. It has been found to be oncogenic and has been implicated in cervical cancers. PIK3CA mutations in breast cancer may be a predictive marker to guide the selection of patients who would benefit from mTOR inhibitor therapy. In addition to that, the presence of PIK3CA mutation may predict response to aspirin therapy for colorectal cancer, indicating power and promise of "Molecular Pathological Epidemiology (MPE)" approach as well as a complex interaction within the tumor microenvironment in this phenomenon.

Uniprot ID

P42336

文献引用格式

PI3 Kinase p110 Alpha/PIK3CA Antibody (Clone#OTI7A7) (Boster Biological Technology, Wuhan, China. Catalog#M00029-2)

应用释义

WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光和免疫细胞化学; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;

Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody (Clone#OTI7A7)

筛选器： All IHC

M00029-2

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Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody (Clone#OTI7A7)

筛选器： All IHC

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