Anti-Lamin A/C Antibody

50μl/1180 100μl/1960 150μl/2780

70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; HGPS; IDC; lamin A; lamin A/C; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; Prelamin A/C; PRO1; progerin

Monoclonal

human

WB, IHC, ICC/IF, IP, FCM

LMNA

Rabbit

IgG

A synthesized peptide derived from human Lamin A/C

74 kDa

70-74 kDa

500 ug/ml; Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide, 0.4-0.5 mg/ml BSA and 50% glycerol.

Affinity-chromatography

Liquid

12 months from date of receipt，-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.

Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A,B and C. The lamin A/C (LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and lamin C. Lamin A/C is mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.

P02545

Lamin A/C Antibody (Boster Biological Technology, Wuhan, China. Catalog#BM4105)

WB-蛋白质免疫印迹法; IHC- 免疫组织化学法; ICC/IF-免疫细胞荧光; ICC－免疫细胞化学; IHC-F- 冰冻切片免疫组化; FCM-流式细胞术; ELISA-酶联免疫吸附测定; IP-免疫沉淀法; IF-免疫组织荧光法; ChIP-染色质免疫沉淀法;

Prelamin-A/C

Western blot (WB):	1:500-2000
Immunohistochemistry (IHC):	1:50-200
Immunocytochemistry/Immunofluorescence (ICC/IF):	1:50-200
ImmunoPrecipitation (IP):	1:20
Flow Cytometry (FCM):	1:20